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The data show that the C159S variant resolves an additional state that is not observed with the SmTGR U597C enzyme presumably as flavin reduction in this form of the enzyme is rapid and this absorption feature is overlapped and additive with the thiolate-FAD charge transfer ( −1 cm −1 and is assigned as charge transfer arising from the proximity of the NADPH dihydronicotinamide ring and the flavin isoalloxazine

Absorption issues

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The association of urinary GSA and disease severity in Crohn’s disease was significant, but not as robust as in ulcerative colitis